Enhanced antitumor efficacy of doxorubicin-encapsulated halloysite nanotubes

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Enhanced antitumor efficacy of doxorubicin-encapsulated halloysite nanotubes

To improve the antitumor efficacy of doxorubicin (DOX) and provide novel clinical treatment of gastric cancer, halloysite nanotubes (HNTs) loaded with DOX were encapsulated by soybean phospholipid (LIP) and the formed HNTs/DOX/LIP was systematically characterized via different techniques. The in vitro anticancer activity of HNTs/DOX/LIP was examined using an MTT assay. The antitumor efficacy an...

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Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes.

Halloysite nanotube (HNT)-based supramolecular complexes are synthesized and evaluated with respect to their cytotoxicity and effects on cellular structures. As HNTs are water-insoluble, DNA is applied for wrapping the surface of HNTs to enhance their water-dispersibility. To investigate the potential of DNA-wrapped HNTs (HD) as a promising drug delivery carrier, doxorubicin (DOX) is introduced...

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ژورنال

عنوان ژورنال: International Journal of Nanomedicine

سال: 2017

ISSN: 1178-2013

DOI: 10.2147/ijn.s143928